Abstract: Laboratory animals are one of the important basic research conditions that support technological innovation in fields such as life sciences and biomedicine. With the transformation of scientific research paradigms, accurately grasping the forefront of science and major national needs, further refining the difficulties and doubts in the creation and development of laboratory animal resources, is of great significance for accelerating the development of new varieties/ strains of laboratory animals and animal model creation and development. The paper reviews the construction and application of laboratory animal resources in China, and deeply explores the main problems in responding to the transformation of scientific research paradigms under the new situation. It also looks forward to new trends in the development of experimental animal resources in China, in order to provide a new perspective for the research and development of new experimental animal resources.

Key words: laboratory animals, animal models, research paradigm, problem condensation, innovative thinking;new perspective

摘要： 实验动物是支撑生命科学和生物医药等领域科技创新的重要基础科研条件之一。 随着科研范式的变革,准确把握科学前沿和国家重大需求,进一步凝练实验动物资源创制与发展中的难点和疑点,对加快推动实验动物新品种 / 新品系开发和动物模型创制与发展具有重要意义。 本文梳理了我国实验动物资源建设和应用情况,就应对新形势下的科研范式变革中存在的主要问题进行了深入探讨,展望了我国实验动物资源发展新动向,以期为实验动物新资源研究开发提供新视角。

关键词: 实验动物, 动物模型, 科研范式, 问题凝练, 创新思维, 新视角